Background selection and biased gene conversion affect more than 95% of the human genome and bias demographic inferences
نویسندگان
چکیده
منابع مشابه
Selection and biased gene conversion in a multigene family: consequences of interallelic bias and threshold selection.
In a previous paper, I investigated the interactions in a gene family of additive selection and biased gene conversion in a finite population when conversion events are rare. Here I extend my "weak-conversion limit" model by allowing biased interallelic conversion (conversion between alleles at the same locus) of arbitrary frequency and various threshold selection schemes for rare interlocus co...
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15 صفحه اولBiased clustered substitutions in the human genome: the footprints of male-driven biased gene conversion.
We examined fixed substitutions in the human lineage since divergence from the common ancestor with the chimpanzee, and determined what fraction are AT to GC (weak-to-strong). Substitutions that are densely clustered on the chromosomes show a remarkable excess of weak-to-strong "biased" substitutions. These unexpected biased clustered substitutions (UBCS) are common near the telomeres of all au...
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ژورنال
عنوان ژورنال: Journal of Test Deposits
سال: 2019
ISSN: 0198-8220
DOI: 10.5555/5638632